| http://purl.uniprot.org/citations/25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25976672 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6(f/f) and PGR(cre/+)Mig-6(f/f) (Mig-6(d/d)) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6(d/d) uterus treated with vehicle as compared with Mig-6(f/f) mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6(d/d) mice showed a significant increase in the number of proliferative cells compared to Mig-6(f/f) mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGR(cre/+)Cited2(f/f); Cited2(d/d)). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.04.146"xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Dunwoodie S.L."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Kim T.H."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Jeong J.W."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/author | "Ku B.J."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/pages | "409-414"xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/title | "Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling."xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://purl.uniprot.org/core/volume | "462"xsd:string |
| http://purl.uniprot.org/citations/25976672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25976672 |
| http://purl.uniprot.org/citations/25976672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25976672 |
| http://purl.uniprot.org/uniprot/O35740#attribution-73E6A1E95B5D1BF476ACC48CB2632605 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/Q99JZ7#attribution-73E6A1E95B5D1BF476ACC48CB2632605 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7B1-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_Q3UUZ5-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_O35740-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_Q3UQA6-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_Q8BZ29-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_Q00175-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |
| http://purl.uniprot.org/uniprot/#_Q3TJN8-mappedCitation-25976672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25976672 |