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http://purl.uniprot.org/citations/25980602http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25980602http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25980602http://www.w3.org/2000/01/rdf-schema#comment"The identification of a second functional dihydrofolate reductase enzyme in humans, DHFRL1, led us to consider whether this is also a feature of rodents. We demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme. While our phylogenetic analysis revealed that RNA-mediated DHFR duplication events did occur across the mammal tree, the duplicates in brown rat and mouse are likely to be processed pseudogenes. Humans have evolved the need for two separate enzymes while laboratory rats and mice have just one."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2015.05.017"xsd:string
http://purl.uniprot.org/citations/25980602http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2015.05.017"xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Hughes L."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Hughes L."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"O'Connell M.J."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"O'Connell M.J."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Deinum E.E."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Deinum E.E."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Parle-McDermott A."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Parle-McDermott A."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Carton R."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Carton R."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"McEntee G."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"McEntee G."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Minguzzi S."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/author"Minguzzi S."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/pages"1855-1862"xsd:string
http://purl.uniprot.org/citations/25980602http://purl.uniprot.org/core/pages"1855-1862"xsd:string