| http://purl.uniprot.org/citations/25987607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25987607 | http://www.w3.org/2000/01/rdf-schema#comment | "The minus ends of spindle microtubules are anchored to a microtubule-organizing center. The conserved Msd1/SSX2IP proteins are localized to the spindle pole body (SPB) and the centrosome in fission yeast and humans, respectively, and play a critical role in microtubule anchoring. In this paper, we show that fission yeast Msd1 forms a ternary complex with another conserved protein, Wdr8, and the minus end-directed Pkl1/kinesin-14. Individual deletion mutants displayed the identical spindle-protrusion phenotypes. Msd1 and Wdr8 were delivered by Pkl1 to mitotic SPBs, where Pkl1 was tethered through Msd1-Wdr8. The spindle-anchoring defect imposed by msd1/wdr8/pkl1 deletions was suppressed by a mutation of the plus end-directed Cut7/kinesin-5, which was shown to be mutual. Intriguingly, Pkl1 motor activity was not required for its anchoring role once targeted to the SPB. Therefore, spindle anchoring through Msd1-Wdr8-Pkl1 is crucial for balancing the Cut7/kinesin-5-mediated outward force at the SPB. Our analysis provides mechanistic insight into the spatiotemporal regulation of two opposing kinesins to ensure mitotic spindle bipolarity."xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201412111"xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/author | "Yukawa M."xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/author | "Ikebe C."xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/pages | "549-562"xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/title | "The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies."xsd:string |
| http://purl.uniprot.org/citations/25987607 | http://purl.uniprot.org/core/volume | "209"xsd:string |
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