| http://purl.uniprot.org/citations/25987726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25987726 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP kinases is required for BAFF-R to promote B cell survival. However, these inhibitors are now known to also inhibit MEK5, which activates the related MAP kinase ERK5. In the present study, we demonstrated that BAFF-induced B cell survival was actually independent of ERK1/2 activation but required ERK5 activation. Consistent with this, we showed that conditional deletion of ERK5 in B cells led to a pronounced global reduction in mature B2 B cell numbers, which correlated with impaired survival of ERK5-deficient B cells after BAFF stimulation. ERK5 was required for optimal BAFF up-regulation of Mcl1 and Bcl2a1, which are prosurvival members of the Bcl-2 family. However, ERK5 deficiency did not alter BAFF activation of the PI3-kinase-Akt or NF-κB signaling pathways, which are also important for BAFF to promote mature B cell survival. Our study reveals a critical role for the MEK5-ERK5 MAP kinase signaling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20142127"xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/author | "Tybulewicz V.L."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/author | "Ley S.C."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/author | "Schweighoffer E."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/author | "Jacque E."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/pages | "883-892"xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/title | "BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival."xsd:string |
| http://purl.uniprot.org/citations/25987726 | http://purl.uniprot.org/core/volume | "212"xsd:string |
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