| http://purl.uniprot.org/citations/25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25987743 | http://www.w3.org/2000/01/rdf-schema#comment | "Siglec-G, a member of the sialic acid-binding Ig-like lectin (Siglec) family, is expressed on B cell and dendritic cell surfaces. It acts as an inhibitory coreceptor and modulates B cell activation, especially on B1 cells, as Siglec-G-deficient mice show mainly a B1 cell-restricted phenotype resulting in increased B1 cell numbers. Although higher B1 cell numbers are discussed to be associated with autoimmunity, loss of Siglec-G does not result in autoimmune disease in BALB/c mice. However, there is evidence from Siglec-G × CD22 double-deficient mice and Siglec-G(-/-) mice on an autoimmune-prone MRL/lpr background that Siglec-G is important to maintain tolerance in B cells. In this study, we analyzed the role of Siglec-G in induction and maintenance of B cell tolerance on C57BL/6 background and in the FcγRIIb-deficient background. We find that aging Siglec-G-deficient and Siglec-G × FcγRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis. Aging Siglec-G-deficient mice have elevated numbers of plasma cells and germinal center B cells, as well as a higher number of activated CD4 T cells, which likely all contribute to autoantibody production. Additional loss of the inhibitory receptor FcγRIIb in Siglec-G(-/-) mice does not result in exacerbation of disease. These results indicate that Siglec-G is important to maintain tolerance in B cells and prevent autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1403139"xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Muller J."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Nitschke L."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Nimmerjahn F."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Daniel C."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Schwab I."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Acs A."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/author | "Lunz B."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/pages | "51-60"xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/title | "Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice."xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/25987743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25987743 |
| http://purl.uniprot.org/citations/25987743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25987743 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1E6-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G1-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_P08101-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_Q8BTG2-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_Q8BY18-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_P97918-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/#_Q80ZE3-mappedCitation-25987743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25987743 |
| http://purl.uniprot.org/uniprot/Q80ZE3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25987743 |