| http://purl.uniprot.org/citations/25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25990242 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8(+) T cells provide protection against pathogens and cancer. After encountering a pathogenic antigen, CD8(+) T cells undergo a triphasic program of rapid proliferation, contraction, and memory formation. Most (∼90-95%) CD8(+) T cells die after vigorous proliferation in the T cell contraction phase, yet the mechanism that triggers apoptotic T cell death remains elusive. This study tested the hypothesis that differential cell-surface expression of M6PR, a multifunctional receptor that regulates lysozyme biogenesis, but also uptakes apoptosis-inducing serine-protease Gzm-B, critically determines life vs. death decisions in T cells. We demonstrate that M6PR-expression on CD8(+) T cell surfaces is dynamically regulated during LmOVA bacterial infection. Notably, time-lapse, confocal microscopy and flow cytometry confirms that M6PR(low) effectors, but not M6PR(high) effectors, escape Gzm-B lethal-hit derived from CD4(+)25(+) Treg cells. Adoptive cotransfer of M6PR(low) effectors and M6PR(high) effectors sorted from LmOVA-infected, congenic mice at the peak of CD8(+) T cell response, reveals that M6PR(low) effectors with the CD8(+) T cell memory precursor phenotype preferentially survive the CD8(+) T cell contraction and differentiate into functional, long-lasting memory CD8(+) T cells. Taken together, our data provide the first evidence, to our knowledge, that selective M6PR down-regulation has a critical role in CD8(+) T cell survival, and our findings have implications for efficient vaccine design and immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.2hi0215-049rr"xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/author | "Xiang J."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/author | "Mousseau D.D."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/author | "Griebel P."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/author | "Ahmed K.A."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/pages | "313-318"xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/title | "Differential expression of mannose-6-phosphate receptor regulates T cell contraction."xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/25990242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25990242 |
| http://purl.uniprot.org/citations/25990242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25990242 |
| http://purl.uniprot.org/uniprot/#_P11032-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_B9EKB8-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_B7ZWC4-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
| http://purl.uniprot.org/uniprot/#_D6RG55-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |
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| http://purl.uniprot.org/uniprot/#_Q62327-mappedCitation-25990242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25990242 |