| http://purl.uniprot.org/citations/26000719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26000719 | http://www.w3.org/2000/01/rdf-schema#comment | "The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related factors, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, in the maintenance of intestinal stem cells (ISCs) in the adultDrosophila midgut. We explored the role of ATM and ATR, utilizing immunostaining with an anti-pS/TQ antibody as an indicator of ATM/ATR activation, γ-irradiation as a DNA damage inducer, and the UAS/GAL4 system for cell type-specific knockdown of ATM, ATR, or both during adulthood. The results showed that the pS/TQ signals got stronger with age and after oxidative stress. The pS/TQ signals were found to be more dependent on ATR rather than on ATM in ISCs/enteroblasts (EBs). Furthermore, an ISC/EB-specific knockdown of ATR, ATM, or both decreased the number of ISCs and oxidative stress-induced ISC proliferation. The phenotypic changes that were caused by the ATR knockdown were more pronounced than those caused by the ATM knockdown; however, our data indicate that ATR and ATM are both needed for ISC maintenance and proliferation; ATR seems to play a bigger role than does ATM."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.100743"xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Jeon H.J."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Yoo M.A."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Na H.J."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/author | "Pyo J.H."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/pages | "307-318"xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/title | "Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26000719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26000719 |
| http://purl.uniprot.org/citations/26000719 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26000719 |
| http://purl.uniprot.org/uniprot/#_P17336-mappedCitation-26000719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26000719 |
| http://purl.uniprot.org/uniprot/#_Q5EAK6-mappedCitation-26000719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26000719 |
| http://purl.uniprot.org/uniprot/#_Q9VXG8-mappedCitation-26000719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26000719 |
| http://purl.uniprot.org/uniprot/Q9VXG8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26000719 |
| http://purl.uniprot.org/uniprot/P17336 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26000719 |
| http://purl.uniprot.org/uniprot/Q5EAK6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26000719 |