http://purl.uniprot.org/citations/26001393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26001393 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesTo investigate the roles of high-mobility group box 1 (HMGB1) protein in lymphangiogenesis and lymphatic node metastasis in colon cancer.MethodsArchival tumour specimens from patients with colon cancer were analysed in this retrospective immunohistochemical study. HMGB1, vascular endothelial growth factor C (VEGF-C) and podoplanin protein levels were analysed immunohistochemically. In vitro studies using the colon cancer cell line HCT116 were also undertaken to investigate the relationship between HMGB1, VEGF-C and nuclear factor (NF)-κB.ResultsSpecimens from 70 patients with colon cancer were reviewed. The presence of positive HMGB1 immunohistochemical staining significantly correlated with lymphatic microvessel density, lymph node metastasis and VEGF-C immunohistochemical staining in colon cancer specimens. The presence of positive VEGF-C immunohistochemical staining significantly correlated with lymph node metastasis. The in vitro studies demonstrated that HMGB1 upregulated VEGF-C mRNA and protein in a dose-dependent manner in HCT116 cells, and that this was mediated via NF-κB.ConclusionsHMGB1 immunohistochemical staining was significantly associated with lymphangiogenesis and lymphatic node metastasis in colon cancer. There was evidence that HMGB1 upregulates VEGF-C by activating NF-κB in a colon cancer cell line."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.org/dc/terms/identifier | "doi:10.1177/0300060515581671"xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/author | "He J."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/author | "Liang H."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/author | "Zhong D."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/name | "J Int Med Res"xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/pages | "494-505"xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/title | "High-mobility group box 1 protein activating nuclear factor-kappaB to upregulate vascular endothelial growth factor C is involved in lymphangiogenesis and lymphatic node metastasis in colon cancer."xsd:string |
http://purl.uniprot.org/citations/26001393 | http://purl.uniprot.org/core/volume | "43"xsd:string |
http://purl.uniprot.org/citations/26001393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26001393 |
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