| http://purl.uniprot.org/citations/26003139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26003139 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to define the role of testicular α1-adrenergic receptors (α1-ADRs) in stress-triggered adaptation of testosterone-producing Leydig cells of adult rats. Results showed that in vivo blockade of testicular α1-ADRs prevented partial recovery of circulating androgen levels registered after 10× repeated immobilization stress (10 × IMO). Moreover, α1-ADR-blockade diminished 10 × IMO-triggered recovery of Leydig cell androgen production, and abolished mitochondrial membrane potential recovery. In the same cells, 10 × IMO-induced increase in Star transcript was abolished, Lhcgr transcript decreased, while transcription of other steroidogenic proteins was not changed. α1-ADR-blockade recovered stress-induced decrease of Nur77, one of the main steroidogenic stimulator, while significantly reduced 10 × IMO-increased in the transcription of the main steroidogenic repressors, Arr19 and Dax1. In vitro experiments revealed an adrenaline-induced α1-ADR-mediated decrease in Nur77 transcription in Leydig cells. Adrenaline-induced increase of repressor Dax1 also involves ADRs in Leydig cells. Accordingly, α1-ADRs participate in some of the stress-triggered effects on the steroidogenic machinery of Leydig cells."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2015.05.019"xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Andric S.A."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Janjic M.M."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Kostic T.S."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Bjelic M.M."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Mihajlovic A.I."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Baburski A.Z."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Sokanovic S.J."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Radovic S.M."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/author | "Stojkov-Mimic N.J."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/pages | "309-319"xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/title | "Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats."xsd:string |
| http://purl.uniprot.org/citations/26003139 | http://purl.uniprot.org/core/volume | "412"xsd:string |
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