| http://purl.uniprot.org/citations/26011700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26011700 | http://www.w3.org/2000/01/rdf-schema#comment | "Metal prostheses of artificial joints undergo wear, producing numerous metal particles and ions, such as Cr3+ . Cr3+ is considered a key factor leading to aseptic loosening. Many studies focus on the effect of Cr3+ on osteoblasts; however, little is known about the effect of Cr3+ on the B-cell maturation antigen (BCMA) in the osteoblasts. In this study, we first demonstrated the BCMA expressed in human SaOS-2 osteoblasts through reverse transcriptase-PCR, Western blot, and immunocytochemical analyses. Cr3+ decreased alkaline phosphatase (ALP), osteocalcin (OC), cell mineralization, and collagen type I mRNA and protein expression. Moreover, Cr3+ has an inhibitive effect on the expression of the BCMA in human SaOS-2 osteoblasts. However, after we upregulated the expression of the BCMA, ALP, OC, cell mineralization, and collagen type I mRNA and protein expression were increased. Overall, this study demonstrates that the BCMA is involved in human SaOS-2 osteoblast osteogenetic metabolism and plays a regulatory role on the toxic effect of chromium ions on human SaOS-2 osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.org/dc/terms/identifier | "doi:10.1002/bab.1401"xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Xu W.D."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Li D.H."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Yang S.S."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Zhou J.S."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Zhang Z.W."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/author | "Miao M.Y."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/name | "Biotechnol Appl Biochem"xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/pages | "638-646"xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/title | "Regulatory role of B-cell maturation antigen on the toxic effect of chromium ions on human SaOS-2 osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/26011700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26011700 |
| http://purl.uniprot.org/citations/26011700 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26011700 |
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| http://purl.uniprot.org/uniprot/#_Q6PE46-mappedCitation-26011700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26011700 |
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| http://purl.uniprot.org/uniprot/A7KBT4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26011700 |