Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/26017882http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26017882http://www.w3.org/2000/01/rdf-schema#comment"

Aim of the study

The XRCC2 gene plays a crucial role in double-strand DNA break repair by homologous recombination. Current literature provides clear evidence that XRCC2 polymorphisms may be associated with the development of certain types of cancer; however, still little is known about their association with endometrial cancer (EC).

Material and methods

The single nucleotide polymorphism (SNP) -41657C/T (rs718282) of the XRCC2 gene was investigated by PCR-RFLP in 304 patients with EC and in 200 age- and sex-matched non-cancer controls.

Results

The analysis revealed a relationship between XRCC2 -41657C/T polymorphism and the incidence of EC. Endometrial cancer patients showed overrepresentation of the T allele of the SNP. The T/T homozygous variant increased the cancer risk. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups according to histological grade.

Conclusions

This is the first study that links the SNP -41657C/T (rs718282) of the XRCC2 gene with EC in Polish women. The results support the hypothesis that this polymorphism may be positively correlated with the incidence of EC."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.org/dc/terms/identifier"doi:10.5114/pjp.2015.51155"xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/author"Smolarz B."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/author"Samulak D."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/author"Romanowicz H."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/author"Michalska M.M."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/author"Bienkiewicz J."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/name"Pol J Pathol"xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/pages"67-71"xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/title"Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women."xsd:string
http://purl.uniprot.org/citations/26017882http://purl.uniprot.org/core/volume"66"xsd:string
http://purl.uniprot.org/citations/26017882http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26017882
http://purl.uniprot.org/citations/26017882http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26017882
http://purl.uniprot.org/uniprot/#_A0A384MEK2-mappedCitation-26017882http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26017882
http://purl.uniprot.org/uniprot/#_O43543-mappedCitation-26017882http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26017882
http://purl.uniprot.org/uniprot/#_Q68DV8-mappedCitation-26017882http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26017882
http://purl.uniprot.org/uniprot/Q68DV8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26017882
http://purl.uniprot.org/uniprot/A0A384MEK2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26017882
http://purl.uniprot.org/uniprot/O43543http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26017882