| http://purl.uniprot.org/citations/26018083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26018083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26018083 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of different glycosphingolipids (GSLs) to activate type I natural killer T cells (NKT cells) has been known for 2 decades. The possible therapeutic use of these GSLs has been studied in many ways; however, studies are needed in which the efficacy of promising GSLs is compared under identical conditions. Here, we compare five unique GSLs structurally derived from α-galactosylceramide. We employed biophysical and biological assays, as well as x-ray crystallography to study the impact of the chemical modifications of the antigen on type I NKT cell activation. Although all glycolipids are bound by the T cell receptor of type I NKT cells in real time binding assays with high affinity, only a few activate type I NKT cells in in vivo or in vitro experiments. The differences in biological responses are likely a result of different pharmacokinetic properties of each lipid, which carry modifications at different parts of the molecule. Our results indicate a need to perform a variety of assays to ascertain the therapeutic potential of type I NKT cell GSL activators."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.654814"xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.654814"xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M115.654814"xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Tsuji M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Tsuji M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Van Calenbergh S."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Van Calenbergh S."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Kronenberg M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Kronenberg M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Howell A."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Howell A."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Chitale S."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Chitale S."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Girardi E."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Girardi E."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Zajonc D.M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Zajonc D.M."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Farber E."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Farber E."xsd:string |
| http://purl.uniprot.org/citations/26018083 | http://purl.uniprot.org/core/author | "Khurana A."xsd:string |