| http://purl.uniprot.org/citations/26018806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26018806 | http://www.w3.org/2000/01/rdf-schema#comment | "The importance of Galectin-3 (Gal-3) in obesity-associated liver pathology is incompletely defined. To dissect the role of Gal-3 in fibrotic nonalcoholic steatohepatitis (NASH), Gal-3-deficient (LGALS3(-/-)) and wild-type (LGALS3(+/+)) C57Bl/6 mice were placed on an obesogenic high fat diet (HFD, 60% kcal fat) or standard chow diet for 12 and 24 wks. Compared to WT mice, HFD-fed LGALS3(-/-) mice developed, in addition to increased visceral adiposity and diabetes, marked liver steatosis, which was accompanied with higher expression of hepatic PPAR-γ, Cd36, Abca-1 and FAS. However, as opposed to LGALS3(-/-) mice, hepatocellular damage, inflammation and fibrosis were more extensive in WT mice which had an elevated number of mature myeloid dendritic cells, proinflammatory CD11b(+)Ly6C(hi) monocytes/macrophages in liver, peripheral blood and bone marrow, and increased hepatic CCL2, F4/80, CD11c, TLR4, CD14, NLRP3 inflammasome, IL-1β and NADPH-oxidase enzymes mRNA expression. Thus, obesity-driven greater steatosis was uncoupled with attenuated fibrotic NASH in Gal-3-deficient mice. HFD-fed WT mice had a higher number of hepatocytes that strongly expressed IL-33 and hepatic CD11b(+)IL-13(+) cells, increased levels of IL-33 and IL-13 and up-regulated IL-33, ST2 and IL-13 mRNA in liver compared with LGALS3(-/-) mice. IL-33 failed to induce ST2 upregulation and IL-13 production by LGALS3(-/-) peritoneal macrophages in vitro. Administration of IL-33 in vivo enhanced liver fibrosis in HFD-fed mice in both genotypes, albeit to a significantly lower extent in LGALS3(-/-) mice, which was associated with less numerous hepatic IL-13-expressing CD11b(+) cells. The present study provides evidence of a novel role for Gal-3 in regulating IL-33-dependent liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.org/dc/terms/identifier | "doi:10.2119/molmed.2014.00178"xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Lukic M.L."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Pantic J."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Pejnovic N."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Arsenijevic N."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Jovicic N."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/author | "Jeftic I."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/name | "Mol Med"xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/pages | "453-465"xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/title | "Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis."xsd:string |
| http://purl.uniprot.org/citations/26018806 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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