| http://purl.uniprot.org/citations/26025651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26025651 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver fibrosis is linked to VEGF-induced angiogenesis. Overexpression of exogenous vasohibin-1, a feedback inhibitor of angiogenesis, has been reported to reduce liver fibrosis after bile duct ligation (BDL). To uncover the function of endogenous vasohibin-1, we performed BDL using vasohibin-1-deficient mice and analyzed liver fibrosis, injury, and angiogenesis. Liver fibrosis was induced by 14-days of BDL in both wild-type and vasohibin-1-deficient mice. The liver sections were stained with anti-CD31 to visualize endothelial cells and with Sirius red to observe fibrotic regions. Total RNAs were purified from the livers and expression of collagen I α1 mRNA was measured by quantitative PCR. Plasma ALT activity was determined to assess liver injury. Surprisingly, the same extents of increases were seen in anti-CD31 and Sirius red stainings, collagen I α1 mRNA expressions, hepatic hydroxyproline contents, and ALT activity after 14-days of BDL in both wild-type and vasohibin-1-deficient mice. There was unexpectedly no difference between these mice, suggesting that anti-fibrogenic and angiogenic activities of the endogenous vasohibin-1 might be masked in the normal liver at early stage of hepatic fibrosis in mice."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.05.074"xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/author | "Kojima S."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/author | "Furutani Y."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/author | "Hara M."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/author | "Shiozaki-Sato Y."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/pages | "384-388"xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/title | "Hepatic fibrosis and angiogenesis after bile duct ligation are endogenously expressed vasohibin-1 independent."xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://purl.uniprot.org/core/volume | "463"xsd:string |
| http://purl.uniprot.org/citations/26025651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26025651 |
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