| http://purl.uniprot.org/citations/26026083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26026083 | http://www.w3.org/2000/01/rdf-schema#comment | "Background/aimThe current study investigated the mechanisms underlying the antitumor activity of SB265610, a cysteine-amino acid-cysteine (CXC) chemokines receptor 2 (CXCR2) antagonist.Materials and methodsCell-cycle progression and regulatory molecules were assessed by flow cytometry, immunoblotting, real-time PCR and immunoprecipitation. Target validation was achieved via RNA interference.ResultsG1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 selectivity, persisted upon interleukin 8 (IL8) challenge, and did not affect IL8 downstream target expression. Profiling of G1 regulators revealed cyclin-dependent kinase 2 (CDK2) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 post-translational induction. However, only cyclin D3 and CDK2 contributed towards G1 arrest. Furthermore, SB265610 induced a sustained phosphorylation of the p38MAPK. Pharmacological interference with p38MAPK significantly abrogated SB265610-induced G1 arrest and normalized the expression of cyclin D3, with restoration of its exclusive binding to CDK6, but with weak recovery of CDK2 (Thr160) hypo-phosphorylation.ConclusionThe present study described the mechanisms for the anti-proliferative activity of SB265610 which may be of value in IL8-rich tumor microenvironments."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/author | "Kim B.Y."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/author | "Erikson R.L."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/author | "Ahn J.S."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/author | "Goda A.E."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/name | "Anticancer Res"xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/pages | "3235-3243"xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/title | "Induction of G1 Arrest by SB265610 Involves Cyclin D3 Down-regulation and Suppression of CDK2 (Thr160) Phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/26026083 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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