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http://purl.uniprot.org/citations/26026129http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26026129http://www.w3.org/2000/01/rdf-schema#comment"

Background

The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. The present study demonstrated that KK-LC-1 is expressed in gastric cancer.

Materials and methods

We analyzed the expression of KK-LC-1 and cancer/testis antigens (CTAs) in surgical specimens of 49 gastric carcinomas. The expression of KK-LC-1 and CTAs was assessed using reverse transcription-polymerase chain reaction.

Results

KK-LC-1 expression was observed in gastric carcinomas. The number of lesions with expression of KK-LC-1, Melanoma antigen gene encoding-A1 (MAGE-A1), MAGE-A3 and New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) was 40 (81.6%), 17 (34.7%), 22 (44.9%) and 8 (16.3%) out of the 49 specimens, respectively.

Conclusion

KK-LC-1 should be categorized as a CTA. The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Kobayashi N."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Takahashi Y."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Watanabe M."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Nishi Y."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Yamazaki H."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Ichiki Y."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Fukuyama T."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Shida A."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/author"Futawatari N."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/pages"3575-3579"xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/title"Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer."xsd:string
http://purl.uniprot.org/citations/26026129http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/26026129http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26026129
http://purl.uniprot.org/citations/26026129http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26026129
http://purl.uniprot.org/uniprot/#_Q5H943-mappedCitation-26026129http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26026129
http://purl.uniprot.org/uniprot/Q5H943http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26026129