| http://purl.uniprot.org/citations/26027733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26027733 | http://www.w3.org/2000/01/rdf-schema#comment | "The homodimeric insulin and type 1 insulin-like growth factor receptors (IR and IGF-1R) share a common architecture and each can bind all three ligands within the family: insulin and insulin-like growth factors I and II (IGF-I and IFG-II). The receptor monomers also assemble as heterodimers, the primary ligand-binding sites of which each comprise the first leucine-rich repeat domain (L1) of one receptor type and an α-chain C-terminal segment (αCT) of the second receptor type. We present here crystal structures of IGF-I bound to such a hybrid primary binding site and of a ligand-free version of an IR αCT peptide bound to an IR L1 plus cysteine-rich domain construct (IR310.T). These structures, refined at 3.0-Å resolution, prove congruent to respective existing structures of insulin-complexed IR310.T and the intact apo-IR ectodomain. As such, they provide key missing links in the emerging, but sparse, repertoire of structures defining the receptor family."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.04.016"xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Lawrence M.C."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Kong G.K."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Ward C.W."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Margetts M.B."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Menting J.G."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/author | "Lawrence C.F."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/pages | "1271-1282"xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/title | "Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors."xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/26027733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26027733 |
| http://purl.uniprot.org/citations/26027733 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26027733 |
| http://purl.uniprot.org/uniprot/#_P08069-mappedCitation-26027733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/#_P05019-mappedCitation-26027733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/#_P15127-mappedCitation-26027733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/#_P06213-mappedCitation-26027733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/P06213 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/P08069 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/P05019 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26027733 |
| http://purl.uniprot.org/uniprot/P15127 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26027733 |