| http://purl.uniprot.org/citations/26028144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26028144 | http://www.w3.org/2000/01/rdf-schema#comment | "The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization and function. Here we use electron microscopy, SIM and dSTORM super-resolution, and live-cell TIRF microscopy to characterize the structural organization and signalling pathways associated with nodule formation. Nodules are composed of up to four actin-rich structures linked together by actin bundles. They are enriched in the adhesion-related proteins talin and vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of integrins at the plasma membrane. Nodule formation is dependent on Wiskott-Aldrich syndrome protein (WASp) and the ARP2/3 complex. WASp(-/-) mouse blood displays impaired platelet aggregate formation at arteriolar shear rates. We propose actin nodules are platelet podosome-related structures required for platelet-platelet interaction and their absence contributes to the bleeding diathesis of Wiskott-Aldrich syndrome."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms8254"xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Pollitt A.Y."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Hartwig J.H."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Davies A."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Watson S.P."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Rappoport J.Z."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Nash G.B."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Thomas S.G."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Thrasher A.J."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Malinova D."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Poulter N.S."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Hannon M.J."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Owen D.M."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/author | "Pikramenou Z."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/pages | "7254"xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/title | "Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex."xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26028144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26028144 |
| http://purl.uniprot.org/citations/26028144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26028144 |
| http://purl.uniprot.org/uniprot/#_A0A087WPR6-mappedCitation-26028144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26028144 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ14-mappedCitation-26028144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26028144 |