| http://purl.uniprot.org/citations/26029823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26029823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26029823 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor (NF)-κB-inducing kinase (NIK) is a serine/threonine kinase that activates NF-κB pathways, thereby regulating a wide variety of immune systems. Aberrant NIK activation causes tumor malignancy, suggesting a requirement for precise regulation of NIK activity. To explore novel interacting proteins of NIK, we performed in vitro virus screening and identified the catalytic subunit Aα isoform of serine/threonine phosphatase calcineurin (CnAα) as a novel NIK-interacting protein. The interaction of NIK with CnAα in living cells was confirmed by co-immunoprecipitation. Calcineurin catalytic subunit Aβ isoform (CnAβ) also bound to NIK. Experiments using domain deletion mutants suggested that CnAα and CnAβ interact with both the kinase domain and C-terminal region of NIK. Moreover, the phosphatase domain of CnAα is responsible for the interaction with NIK. Intriguingly, we found that TRAF3, a critical regulator of NIK activity, also binds to CnAα and CnAβ. Depletion of CnAα and CnAβ significantly enhanced lymphotoxin-β receptor (LtβR)-mediated expression of the NIK-dependent gene Spi-B and activation of RelA and RelB, suggesting that CnAα and CnAβ attenuate NF-κB activation mediated by LtβR-NIK signaling. Overall, these findings suggest a possible role of CnAα and CnAβ in modifying NIK functions."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep10758"xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep10758"xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Akiyama N."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Akiyama N."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Konno H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Konno H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Yanagawa H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Yanagawa H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Ohashi H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Ohashi H."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Miyauchi M."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Miyauchi M."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Miyamoto-Sato E."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Miyamoto-Sato E."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Shinzawa M."xsd:string |
| http://purl.uniprot.org/citations/26029823 | http://purl.uniprot.org/core/author | "Shinzawa M."xsd:string |