| http://purl.uniprot.org/citations/26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26030024 | http://www.w3.org/2000/01/rdf-schema#comment | "During development, progenitor cells with binary potential give rise to daughter cells that have distinct functions. Heritable epigenetic mechanisms then lock in gene-expression programs that define lineage identity. Regulation of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T cells exemplifies this process, with enhancer- and silencer-regulated establishment of epigenetic memory for stable gene expression and repression, respectively. Using a genetic screen, we identified the DNA-methylation machinery as essential for maintaining silencing of Cd4 in the cytotoxic lineage. Furthermore, we found a requirement for the proximal enhancer in mediating the removal of DNA-methylation marks from Cd4, which allowed stable expression of Cd4 in helper T cells. Our findings suggest that stage-specific methylation and demethylation events in Cd4 regulate its heritable expression in response to the distinct signals that dictate lineage 'choice' during T cell development."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3198"xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Green M.R."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Galan C."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Sellars M."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Huh J.R."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Absher D."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Day K."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Gobeil S."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/author | "Issuree P.D."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/pages | "746-754"xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/title | "Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages."xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/26030024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26030024 |
| http://purl.uniprot.org/citations/26030024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26030024 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |
| http://purl.uniprot.org/uniprot/#_D3YXC8-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |
| http://purl.uniprot.org/uniprot/#_E0CYR1-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |
| http://purl.uniprot.org/uniprot/#_P13864-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |
| http://purl.uniprot.org/uniprot/#_Q0VDW2-mappedCitation-26030024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030024 |