| http://purl.uniprot.org/citations/26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26030184 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic determinants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to fibrogenesis in experimental models. To examine the associations between self-identified race and MC1R single-nucleotide polymorphisms (SNPs) with severity of post-burn HTS, we conducted a prospective cohort study of burned adults admitted to our institution over 7 years. Subjects were evaluated using the Vancouver Scar Scale (VSS), asked to rate their itching, and genotyped for 8 MC1R SNPs. Testing for association with severe HTS (VSS>7) and itch severity (0-10) was based on multivariate regression with adjustment for known risk factors. Of 425 subjects analyzed, 77% identified as White. The prevalence of severe HTS (VSS>7) was 49%, and the mean itch score was 3.9. In multivariate analysis, Asian (prevalence ratio (PR) 1.54; 95% CI: 1.13-2.10), Black/African American (PR 1.86; 95% CI: 1.42-2.45), and Native American (PR 1.87; 95% CI: 1.48-2.35) race were independently associated with severe HTS. MC1R SNP R163Q was also significantly (P<0.001) associated with severe HTS. Asian race (linear regression coefficient 1.32; 95% CI: 0.23-2.40) but not MC1R SNP genotype was associated with increased itch score. We conclude that MC1R genotype may influence post-burn scarring."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2015.197"xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Reiner A.P."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Hocking A.M."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Gibran N.S."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Muffley L.A."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Sood R.F."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Ga M."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Honari S."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/author | "Rowhani-Rahbar A."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/pages | "2394-2401"xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/title | "Race and Melanocortin 1 Receptor Polymorphism R163Q Are Associated with Post-Burn Hypertrophic Scarring: A Prospective Cohort Study."xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/26030184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26030184 |
| http://purl.uniprot.org/citations/26030184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26030184 |
| http://purl.uniprot.org/uniprot/#_Q1JUM0-mappedCitation-26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030184 |
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| http://purl.uniprot.org/uniprot/#_Q1JUM4-mappedCitation-26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030184 |
| http://purl.uniprot.org/uniprot/#_Q1JUM5-mappedCitation-26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030184 |
| http://purl.uniprot.org/uniprot/#_B3KNP6-mappedCitation-26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030184 |
| http://purl.uniprot.org/uniprot/#_Q86YW1-mappedCitation-26030184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26030184 |