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Aim

Killer immunoglobulin-like receptors (KIRs) and their interaction with HLA class I ligands have been shown to be associated with Type 1 diabetes mellitus. The aim of our study was to investigate the influence of KIR genes and their HLA-C ligands for susceptibility to Type 1 diabetes in patients from Eastern India.

Methods

A total of 135 patients with Type 1 diabetes and 98 healthy subjects from Eastern India were typed for KIR genes and HLA-C ligands using PCR-based genotyping. The frequencies of these genes were compared between patients and controls.

Results

Comparison of KIR genes between Type 1 diabetes patients and healthy subjects revealed significantly different frequencies of KIRs 2DL2 and 2DS4. The presence of HLA-C1 was negatively associated with disease. The presence of both HLA-C1 and -C2 showed a negative association with Type 1 diabetes, whereas the absence of C1 and presence of C2 was positively associated with disease. Stratification analysis of HLA-C ligands and KIRs showed significant associations between Type 1 diabetes and 2DL2+/C1-, 2DL2-/C1+, 2DL3+/C1+, 2DL3+/C1- and 2DS2+/C1-.

Conclusions

Our results suggest that the interaction of KIRs with HLA-C ligands are significant and certain combinations contribute to susceptibility to and protection against Type 1 diabetes."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.org/dc/terms/identifier"doi:10.1111/dme.12815"xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/author"Sun C."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/author"Sanjeevi C.B."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/author"Kanungo A."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/author"Sanjeevi S."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/name"Diabet Med"xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/pages"91-96"xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/title"Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population."xsd:string
http://purl.uniprot.org/citations/26031759http://purl.uniprot.org/core/volume"33"xsd:string
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