| http://purl.uniprot.org/citations/26032417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26032417 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate stem cells (P-SCs) are capable of giving rise to all three lineages of prostate epithelial cells, which include basal, luminal, and neuroendocrine cells. Two types of P-SCs have been identified in both human and mouse adult prostates based on prostasphere or organoid cultures, cell lineage tracing, renal capsule implantation, and expression of luminal- and basal-specific proteins. The sphere-forming P-SCs are from the basal cell compartment that express P63, and are therefore designated as basal P-SCs (P-bSCs). Luminal P-SCs (P-lSCs) express luminal cytokeratins and Nkx3.1. Herein, we report that the type 2 FGF receptor (FGFR2) signaling axis is crucial for preserving stemness and preventing differentiation of P-bSCs. FGFR2 signaling mediated by FGFR substrate 2α (FRS2α) is indispensable for formation and maintenance of prostaspheres derived from P63(+) P-bSCs. Ablation of Fgfr2 in P63(+) cells in vitro causes the disintegration of prostaspheres. Ablation of Fgfr2 in vivo reduces the number of P63-expressing basal cells and enriches luminal cells. This suggests a basal stem cell-to-luminal cell differentiation. In addition, ablation of Fgfr2 in P63(+) cells causes defective postnatal development of the prostate. Therefore, the data indicate that FGFR2 signaling is critical for preserving stemness and preventing differentiation of P-bSCs."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.661066"xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Jin C."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "McKeehan W.L."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "An L."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "You P."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Hamana T."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/author | "Chang J.Y.F."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/pages | "17753-17761"xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/title | "Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment."xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/26032417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26032417 |
| http://purl.uniprot.org/citations/26032417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26032417 |
| http://purl.uniprot.org/uniprot/#_D3YW77-mappedCitation-26032417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26032417 |
| http://purl.uniprot.org/uniprot/#_D3Z5M8-mappedCitation-26032417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26032417 |
| http://purl.uniprot.org/uniprot/#_E9Q700-mappedCitation-26032417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26032417 |