| http://purl.uniprot.org/citations/26033031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26033031 | http://www.w3.org/2000/01/rdf-schema#comment | "PFTK1 was a cell division cycle 2-related serine/threonine protein kinase, which was up-regulated in breast cancer tissues and breast cancer lines. And up-regulated PFTK1 was highly associated with grade, axillary lymph node status, and Ki-67. Moreover, Kaplan-Meier curve showed that up-regulated PFTK1 was related to the poor breast carcinoma patients' overall survival. Here, we first discovered and confirmed that cyclin B was a new interacting protein of PFTK1, and the complex might increase the amount of DVL2, which triggers Wnt/β-catenin signaling pathway. Furthermore, knockdown of PFTK1 attenuated cell proliferation, anchorage-independent cell growth, and cell migration and invasion by inhibiting the transcriptional activation of β-catenin for cyclin D1, MMP9, and HEF1, whereas exogenous expression of PFTK1 might promote MDA-MB-231 cells proliferation, migration, and invasion via promoting PFTK1-DVL2-β-catenin axis. Our findings supported the notion that up-regulated PFTK1 might promote breast cancer progression and metastasis by activating Wnt signaling pathway through the PFTK1-DVL2-β-catenin axis."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12032-015-0641-8"xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Mao G."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/author | "Ni Q."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/name | "Med Oncol"xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/pages | "195"xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/title | "Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/26033031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26033031 |
| http://purl.uniprot.org/citations/26033031 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26033031 |
| http://purl.uniprot.org/uniprot/#_B4DK59-mappedCitation-26033031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26033031 |
| http://purl.uniprot.org/uniprot/#_E7EUK8-mappedCitation-26033031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26033031 |
| http://purl.uniprot.org/uniprot/#_O94921-mappedCitation-26033031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26033031 |
| http://purl.uniprot.org/uniprot/E7EUK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26033031 |
| http://purl.uniprot.org/uniprot/B4DK59 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26033031 |