| http://purl.uniprot.org/citations/26033476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26033476 | http://www.w3.org/2000/01/rdf-schema#comment | "The tyrosine kinase receptor, EphB4, mediates cross-talk between stromal and hematopoietic populations during bone remodeling, fracture repair and arthritis, through its interactions with the ligand, ephrin-B2. This study demonstrated that transgenic EphB4 mice (EphB4 Tg), over-expressing EphB4 under the control of collagen type-1 promoter, exhibited higher frequencies of osteogenic cells and hematopoietic stem/progenitor cells (HSC), correlating with a higher frequency of long-term culture-initiating cells (LTC-IC), compared with wild type (WT) mice. EphB4 Tg stromal feeder layers displayed a greater capacity to support LTC-IC in vitro, where blocking EphB4/ephrin-B2 interactions decreased LTC-IC output. Similarly, short hairpin RNA-mediated EphB4 knockdown in human bone marrow stromal cells reduced their ability to support high ephrin-B2 expressing CD34(+) HSC in LTC-IC cultures. Notably, irradiated EphB4 Tg mouse recipients displayed enhanced bone marrow reconstitution capacity and enhanced homing efficiency of transplanted donor hematopoietic stem/progenitor cells relative to WT controls. Studies examining the expression of hematopoietic supportive factors produced by stromal cells indicated that CXCL12, Angiopoietin-1, IL-6, FLT-3 ligand, and osteopontin expression were more highly expressed in EphB4 Tg stromal cells compared with WT controls. These findings indicate that EphB4 facilitates stromal-mediated support of hematopoiesis, and constitute a novel component of the HSC niche."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.2069"xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Matsuo K."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Nguyen T.M."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Purton L.E."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Paton S."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Hayball J.D."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Zannettino A.C."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Gronthos S."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Arthur A."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/author | "Panagopoulos R."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/pages | "2838-2849"xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/title | "EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance."xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/26033476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26033476 |
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