| http://purl.uniprot.org/citations/26034069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26034069 | http://www.w3.org/2000/01/rdf-schema#comment | "IFT20, a component of the intraflagellar transport (IFT) system that controls ciliogenesis, regulates immune synapse assembly in the non-ciliated T-cell by promoting T-cell receptor (TCR) recycling. Here, we have addressed the role of Rab8 (for which there are two isoforms Rab8a and Rab8b), a small GTPase implicated in ciliogenesis, in TCR traffic to the immune synapse. We show that Rab8, which colocalizes with IFT20 in Rab11(+) endosomes, is required for TCR recycling. Interestingly, as opposed to in IFT20-deficient T-cells, TCR(+) endosomes polarized normally beneath the immune synapse membrane in the presence of dominant-negative Rab8, but were unable to undergo the final docking or fusion step. This could be accounted for by the inability of the vesicular (v)-SNARE VAMP-3 to cluster at the immune synapse in the absence of functional Rab8, which is responsible for its recruitment. Of note, and similar to in T-cells, VAMP-3 interacts with Rab8 at the base of the cilium in NIH-3T3 cells, where it regulates ciliary growth and targeting of the protein smoothened. The results identify Rab8 as a new player in vesicular traffic to the immune synapse and provide insight into the pathways co-opted by different cell types for immune synapse assembly and ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.171652"xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Pazour G.J."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Finetti F."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Baldari C.T."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Perinetti G."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Galgano D."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Patrussi L."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/author | "Cassioli C."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/pages | "2541-2552"xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/title | "The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse."xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/26034069 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26034069 |
| http://purl.uniprot.org/citations/26034069 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26034069 |
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