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http://purl.uniprot.org/citations/26037364http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To verify 3 novel HLA-A alleles A*24:224, A*24:225 and A*24:257 identified in Chinese Han individuals.

Methods

No full matched results were obtained at HLA-A locus in HLA typing for China Marrow Donor Program (CMDP) using bi-allelic Sequence-Based Typing (SBT). The novel HLA alleles were identified with allele-specific amplification SBT.

Results

All of the three probands had a novel nucleotide sequence at HLA-A locus. All of the 3 new sequences are most close to HLA-A*24:02:01:01 except for 1 or 2 nucleotide substitution in exon 2, which resulted in different changes in corresponding codons and encoded amino acids.

Conclusion

Three novel HLA-A alleles were confirmed and officially named as HLA-A*24:224, HLA-A*24:225 and HLA-A*24:257 under the GenBank accession numbers JQ899198, JQ924283 and HG003642 by the WHO Nomenclature Committee for Factors of the HLA System in November 2012 and November 2013, respectively."xsd:string
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http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/author"Zhang H."xsd:string
http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/author"Nie X."xsd:string
http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/author"Zhu C."xsd:string
http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
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http://purl.uniprot.org/citations/26037364http://purl.uniprot.org/core/title"[Identification of 3 novel HLA-A alleles A*24:224, A*24:225 and A*24:257 by sequence-based typing]."xsd:string
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