| http://purl.uniprot.org/citations/26042735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26042735 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophage proliferation and migration are important for many facets of immune response. Here we showed that stimulation of macrophages with type B CpG oligodeoxynucleotides (CpG-B ODNs) such as CpG-ODN 1668 increased the production of anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) in a TLR9- and MyD88-dependent manner. The CpG-B ODNs-induced IL-1Ra increased macrophage migration and promoted macrophage proliferation by down-regulating the expression of a cell cycle negative regulator, p27 to increase cell population in the S phase. The induction of IL-1Ra by CpG-B ODNs was F-spondin dependent. Knockdown of F-spondin and IL-1Ra decreased CpG-B ODNs-induced macrophage migration whereas overexpression of IL-1Ra increased migration of those cells. These findings demonstrated novel roles for F-spondin and IL-1Ra in CpG-B ODNs-mediated cell proliferation and migration of macrophages."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0128926"xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Chen Y.P."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Liao C.C."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Cheng Y.C."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Hsu Y.F."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Liang C.M."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Liang S.M."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/author | "Chen T.A."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/pages | "e0128926"xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/title | "Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent."xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26042735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26042735 |
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