| http://purl.uniprot.org/citations/26044300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26044300 | http://www.w3.org/2000/01/rdf-schema#comment | "Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erbα, a transcription factor (TF) that functions both as a core repressive component of the cell-autonomous clock and as a regulator of metabolic genes. Here, we show that Rev-erbα modulates the clock and metabolism by different genomic mechanisms. Clock control requires Rev-erbα to bind directly to the genome at its cognate sites, where it competes with activating ROR TFs. By contrast, Rev-erbα regulates metabolic genes primarily by recruiting the HDAC3 co-repressor to sites to which it is tethered by cell type-specific transcription factors. Thus, direct competition between Rev-erbα and ROR TFs provides a universal mechanism for self-sustained control of the molecular clock across all tissues, whereas Rev-erbα uses lineage-determining factors to convey a tissue-specific epigenomic rhythm that regulates metabolism tailored to the specific need of that tissue."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aab3021"xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Feng D."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Steger D.J."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Fang B."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Lazar M.A."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Jager J."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Emmett M.J."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Soccio R.E."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Armour S.M."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Damle M."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/author | "Remsberg J.R."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/pages | "1488-1492"xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/title | "GENE REGULATION. Discrete functions of nuclear receptor Rev-erbalpha couple metabolism to the clock."xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://purl.uniprot.org/core/volume | "348"xsd:string |
| http://purl.uniprot.org/citations/26044300 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26044300 |
| http://purl.uniprot.org/citations/26044300 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26044300 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-26044300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26044300 |
| http://purl.uniprot.org/uniprot/#_A0A286YD98-mappedCitation-26044300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26044300 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-26044300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26044300 |