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http://purl.uniprot.org/citations/26044581http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26044581http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Dyslipidemia is implicated in abdominal aortic aneurysms (AAAs) in humans and angiotensin (Ang) II-infused mice. This study determined effects of major lipoprotein classes on AngII-induced AAAs using multiple mouse strains with dietary and pharmacological manipulations.

Approach and results

Western diet had minor effects on plasma cholesterol concentrations and the low incidence of AngII-induced AAAs in C57BL/6J mice. Low incidence of AAAs in this strain was not attributed to protection from high-density lipoprotein, because apolipoprotein (apo) AI deficiency did not increase AngII-induced AAAs. ApoAI deletion also failed to alter AAA occurrence in hypercholesterolemic mice. Low-density lipoprotein receptor-/-mice fed normal diet had low incidence of AngII-induced AAAs. Western diet feeding of this strain provoked pronounced hypercholesterolemia because of increased apoB-containing lipoproteins with attendant increases of atherosclerosis in both sexes, but AAAs only in male mice. ApoE-deficient mice fed normal diet were modestly hypercholesterolemic, whereas this strain fed Western diet was severely hypercholesterolemic because of increased apoB-containing lipoprotein concentrations. The latter augmented atherosclerosis, but did not change the high incidence of AAAs in this strain. To determine whether reductions in apoB-containing lipoproteins influenced AngII-induced AAAs, ezetimibe was administered at a dose that partially reduced plasma cholesterol concentrations to ApoE-deficient mice fed Western diet. This decreased atherosclerosis, but not AAAs. This ezetimibe dose in ApoE-deficient mice fed normal diet significantly decreased plasma apoB-containing lipoprotein concentrations and reduced AngII-induced AAAs.

Conclusions

ApoB-containing lipoproteins contribute to augmentation of AngII-induced AAA in male mice. However, unlike atherosclerosis, AAA occurrence was not correlated with increases in plasma apoB-containing lipoprotein concentrations."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.115.305482"xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Lu H."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Balakrishnan A."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Sorci-Thomas M."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Daugherty A."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Howatt D.A."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Cassis L.A."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/author"Moorleghen J.J."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/pages"1826-1834"xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/title"Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice."xsd:string
http://purl.uniprot.org/citations/26044581http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/26044581http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26044581
http://purl.uniprot.org/citations/26044581http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26044581
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