| http://purl.uniprot.org/citations/26045047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26045047 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-κB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-κB2 processing into p52, a process defined as the alternative, or non-canonical, NF-κB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-dependent apoptosis, a consequence of TNFR1 activation observed in c-IAP1/2-depleted conditions. We show that NIK stabilization, obtained by activation of the non-death TNFRs Fn14 or LTβR, is required for TNFα-mediated apoptosis. These apoptotic stimuli trigger the depletion of c-IAP1/2, the phosphorylation of RIP1 and the RIP1 kinase-dependent assembly of the RIP1/FADD/caspase-8 complex. In the absence of NIK, the phosphorylation of RIP1 and the formation of RIP1/FADD/caspase-8 complex are compromised while c-IAP1/2 depletion is unaffected. In vitro kinase assays revealed that recombinant RIP1 is a bona fide substrate of NIK. In vivo, we demonstrated the requirement of NIK pro-death function, but not the processing of its substrate p100 into p52, in a mouse model of TNFR1/LTβR-induced thymus involution. In addition, we also highlight a role for NIK in hepatocyte apoptosis in a mouse model of virus-induced TNFR1/RIP1-dependent liver damage. We conclude that NIK not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1/RIP1-dependent cell death independently of the alternative NF-κB pathway."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2015.69"xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Piette J."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Becher B."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Dejardin E."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Ricci J.E."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Bertrand M.J."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Marchetti S."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Hupalowska A."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Heikenwalder M."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Mair F."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Caamano J."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Benezech C."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Boutaffala L."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Knolle P."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Remouchamps C."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Janas M."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Ganeff C."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Reisinger F."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Fernandes M.T."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/author | "Seleznik G."xsd:string |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26045047 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |