| http://purl.uniprot.org/citations/26045466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26045466 | http://www.w3.org/2000/01/rdf-schema#comment | "Somatic cell cytokinesis was shown to involve the insertion of sphingolipids (SLs) to midbodies prior to abscission. Spermatogenic midbodies transform into stable intercellular bridges (ICBs) connecting clonal daughter cells in a syncytium. This process requires specialized SL structures. (1) Using high resolution-mass spectrometric imaging, we show in situ a biphasic pattern of SL synthesis with testis-specific anchors. This pattern correlates with and depends on ceramide synthase 3 (CerS3) localization in both, pachytene spermatocytes until completion of meiosis and elongating spermatids. (2) Blocking the pathways to germ cell-specific ceramides (CerS3-KO) and further to glycosphingolipids (glucosylceramide synthase-KO) in mice highlights the need for special SLs for spermatid ICB stability. In contrast to somatic mitosis these SLs require ultra-long polyunsaturated anchors with unique physico-chemical properties, which can only be provided by CerS3. Loss of these anchors causes enhanced apoptosis during meiosis, formation of multinuclear giant cells and spermatogenic arrest. Hence, testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddv204"xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Heid H."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Porubsky S."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Gorgas K."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Jennemann R."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Rabionet M."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Sandhoff R."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Bayerle A."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Guillou F."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Bolenz C."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Marsching C."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/author | "Fuchser J."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/pages | "4792-4808"xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/title | "Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors."xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/26045466 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26045466 |
| http://purl.uniprot.org/citations/26045466 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26045466 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUU0-mappedCitation-26045466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26045466 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUV0-mappedCitation-26045466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26045466 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUY3-mappedCitation-26045466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26045466 |