| http://purl.uniprot.org/citations/26054799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26054799 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinase TOR is found in two complexes, TORC1, which is involved in growth control, and TORC2, whose roles are less well defined. Here, we asked whether TORC2 has a role in sustaining cellular stress. We show that TORC2 inhibition in Drosophila melanogaster leads to a reduced tolerance to heat stress, whereas sensitivity to other stresses is not affected. Accordingly, we show that upon heat stress, both in the animal and Drosophila cultured S2 cells, TORC2 is activated and is required for maintaining the level of its known target, Akt1 (also known as PKB). We show that the phosphorylation of the stress-activated protein kinases is not modulated by TORC2 nor is the heat-induced upregulation of heat-shock proteins. Instead, we show, both in vivo and in cultured cells, that TORC2 is required for the assembly of heat-induced cytoprotective ribonucleoprotein particles, the pro-survival stress granules. These granules are formed in response to protein translation inhibition imposed by heat stress that appears to be less efficient in the absence of TORC2 function. We propose that TORC2 mediates heat resistance in Drosophila by promoting the cell autonomous formation of stress granules."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.168724"xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Hafen E."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Braakman I."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Stocker H."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Rabouille C."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Zacharogianni M."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Aguilera-Gomez A."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "van Oorschot M.M."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "van Zadelhoff G."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Jevtov I."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/author | "Vuillez I."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/pages | "2497-2508"xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/title | "TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules."xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/26054799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26054799 |
| http://purl.uniprot.org/citations/26054799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26054799 |
| http://purl.uniprot.org/uniprot/Q9V719#attribution-C58F336AAA930A0DA068C5625777B559 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26054799 |
| http://purl.uniprot.org/uniprot/Q9VWJ6#attribution-C58F336AAA930A0DA068C5625777B559 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26054799 |
| http://purl.uniprot.org/uniprot/X2JL73#attribution-C58F336AAA930A0DA068C5625777B559 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26054799 |
| http://purl.uniprot.org/uniprot/Q7YU91#attribution-C58F336AAA930A0DA068C5625777B559 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26054799 |
| http://purl.uniprot.org/uniprot/X2JFR5#attribution-C58F336AAA930A0DA068C5625777B559 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26054799 |