http://purl.uniprot.org/citations/26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26056112 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundStudies indicate that human leukocyte antigen (HLA) gene polymorphisms are implicated in the risk of pulmonary tuberculosis (PTB). However, research findings are contradictory.ObjectiveTo examine the association between HLA-DRB1 alleles and PTB risk using a meta-analysis on case-control studies.MethodsWe searched for relevant studies in the PubMed and EMBASE databases. We used fixed-effects or random-effects models and reported combined odds ratios (ORs) and 95% confidence intervals (CI). The Newcastle-Ottawa Scale (NOS) was used to estimate the quality of each case-control study.ResultsA total of 21 individual case-control studies were identified, including studies of 14 family alleles and 28 specific alleles. Compared with controls, DRB1*15 and DRB1*08:03 were found to have significantly higher frequencies in PTB patients; however, DRB1*03, DRB1*11, DRB1*11:03 and DRB1*12:02 had significantly lower frequencies in the total population. The association between other HLA-DRB1 family alleles and specific alleles and predisposition to PTB was not statistically significant. Among Asian populations, DRB1*03 and DRB1*07:01 were associated with a reduced incidence of PTB, while DRB1*15 and DRB1*08:03 were associated with an increased incidence of PTB.ConclusionWe conclude that HLA-DRB1 may be a valuable marker to predict the risk for PTB, especially in Asian populations."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.org/dc/terms/identifier | "doi:10.5588/ijtld.14.0521"xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/author | "He M."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/author | "Xiang X."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/author | "Li C.P."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/author | "Zhou Y.'"xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/name | "Int J Tuberc Lung Dis"xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/pages | "841-849"xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/title | "Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis."xsd:string |
http://purl.uniprot.org/citations/26056112 | http://purl.uniprot.org/core/volume | "19"xsd:string |
http://purl.uniprot.org/citations/26056112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26056112 |
http://purl.uniprot.org/citations/26056112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |
http://purl.uniprot.org/uniprot/#_A0A0A0WB88-mappedCitation-26056112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056112 |