| http://purl.uniprot.org/citations/26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26056150 | http://www.w3.org/2000/01/rdf-schema#comment | "Castration-resistant prostate cancer (CRPC) remains dependent on androgen receptor (AR) signaling. Alternative splicing of the AR to generate constitutively active, ligand-independent variants is one of the principal mechanisms that promote the development of resistance to next-generation antiandrogens such as enzalutamide. Here, we demonstrate that the splicing factor heterogeneous nuclear RNA-binding protein A1 (hnRNPA1) plays a pivotal role in the generation of AR splice variants such as AR-V7. hnRNPA1 is overexpressed in prostate tumors compared with benign prostates, and its expression is regulated by NF-κB2/p52 and c-Myc. CRPC cells resistant to enzalutamide exhibit higher levels of NF-κB2/p52, c-Myc, hnRNPA1, and AR-V7. Levels of hnRNPA1 and AR-V7 are positively correlated with each other in prostate cancer. The regulatory circuit involving NF-κB2/p52, c-Myc, and hnRNPA1 plays a central role in the generation of AR splice variants. Downregulation of hnRNPA1 and consequently of AR-V7 resensitizes enzalutamide-resistant cells to enzalutamide, indicating that enhanced expression of hnRNPA1 may confer resistance to AR-targeted therapies by promoting the generation of splice variants. These findings may provide a rationale for cotargeting these pathways to achieve better efficacy through AR blockade."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.org/dc/terms/identifier | "doi:10.1158/1535-7163.mct-14-1057"xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Tummala R."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Lou W."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Gao A.C."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Evans C.P."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/author | "Nadiminty N."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/name | "Mol Cancer Ther"xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/pages | "1884-1895"xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/title | "NF-kappaB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer."xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/26056150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26056150 |
| http://purl.uniprot.org/citations/26056150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26056150 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_A0A024RB53-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |
| http://purl.uniprot.org/uniprot/#_B3CJB8-mappedCitation-26056150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26056150 |