| http://purl.uniprot.org/citations/26058075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26058075 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the microenvironment in T cell acute lymphoblastic leukemia (T-ALL), or any acute leukemia, is poorly understood. Here we demonstrate that T-ALL cells are in direct, stable contact with CXCL12-producing bone marrow stroma. Cxcl12 deletion from vascular endothelial, but not perivascular, cells impeded tumor growth, suggesting a vascular niche for T-ALL. Moreover, genetic targeting of Cxcr4 in murine T-ALL after disease onset led to rapid, sustained disease remission, and CXCR4 antagonism suppressed human T-ALL in primary xenografts. Loss of CXCR4 targeted key T-ALL regulators, including the MYC pathway, and decreased leukemia initiating cell activity in vivo. Our data identify a T-ALL niche and suggest targeting CXCL12/CXCR4 signaling as a powerful therapeutic approach for T-ALL."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2015.05.002"xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Gong Y."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "King B."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Ferrando A.A."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Schwab S.R."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Aifantis I."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Trimarchi T."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Tsirigos A."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Sanchez-Martin M."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Morrison S.J."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Pitt L.A."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Fooksman D.R."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/author | "Tikhonova A.N."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/pages | "755-768"xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/title | "CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance."xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/26058075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26058075 |
| http://purl.uniprot.org/citations/26058075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26058075 |
| http://purl.uniprot.org/uniprot/#_D0FZQ3-mappedCitation-26058075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26058075 |