| http://purl.uniprot.org/citations/26058359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26058359 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown that the expression of claudin-4 is upregulated in breast cancer. The aim of the present study was to investigate the role and the regulation of claudin-4 in MCF-7 breast cancer cells. For the in vitro experiments, MCF-7 cells were treated with recombinant vectors carrying cDNA for claudin-4 overexpression or short hairpin RNAs (shRNAs) for claudin-4 silencing. Cell proliferation was determined by an MTT assay and cell migration ability was measured by a wound-healing assay. The cell cycle profile and apoptotic rate were analyzed using flow cytometry. The effect of methylation status on claudin-4 expression was determined by PCR and western blotting. For the in vivo tumorigenesis analysis, MCF-7 cells with or without claudin-4 silencing were transplanted into nude mice. In vivo cell growth was evaluated 14 days after transplantation. We found that claudin-4 overexpression increased MCF-7 cell proliferation and migration, and reduced the rate of cell apoptosis. Silencing of claudin-4 induced the opposite effects in MCF-7 cells. In addition, claudin-4 expression was upregulated by demethylation. Moreover, the size of tumor formation was reduced in nude mice transplanted with claudin-4 silenced MCF-7 cells. These observations suggested that claudin-4, which was regulated by methylation status, plays an important role in breast cancer growth and malignancy via the control of cell proliferation, migration and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.org/dc/terms/identifier | "doi:10.3892/or.2015.4037"xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Wen Z."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Pan Q."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Jing B."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/author | "Miao H."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/pages | "681-690"xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/title | "Claudin-4 controls the proliferation, apoptosis, migration and in vivo growth of MCF-7 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/26058359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26058359 |
| http://purl.uniprot.org/citations/26058359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26058359 |
| http://purl.uniprot.org/uniprot/#_B3KW38-mappedCitation-26058359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26058359 |
| http://purl.uniprot.org/uniprot/#_B3KX18-mappedCitation-26058359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26058359 |
| http://purl.uniprot.org/uniprot/#_Q75L80-mappedCitation-26058359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26058359 |
| http://purl.uniprot.org/uniprot/#_O14493-mappedCitation-26058359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26058359 |
| http://purl.uniprot.org/uniprot/B3KW38 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26058359 |