| http://purl.uniprot.org/citations/26062743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26062743 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis B virus (HBV) replicates noncytopathically in hepatocytes, but HBV or proteins encoded by HBV genome could induce cytokines, chemokines expression by hepatocytes.IL-12 is a typical proinflammatory cytokine that plays a critical role in host defense against pathogens, including the HBV. However, the role of IL-12 in chronic hepatitis B (CHB) remains unclear. The aims of this study were to detect the expression of IL-12 in CHB patients and explore the molecular mechanism of HBV-induced IL-12 expression. The results showed that serum levels and hepatic expression of IL-12 were significantly upregulated in CHB patients. HBx protein increased IL-12 expression in a dose-dependent manner. Furthermore, inhibition of PI3K/Akt significantly decreased the HBx-induced IL-12 expression and Akt activation. Taken together, these results indicate that the molecular mechanism of HBV-induced IL-12 expression involves activation of the PI3K/Akt pathway by HBx, leading to transactivation of the IL-12 p35 and p40 promoters."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-015-2463-6"xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/author | "Wang H.W."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/author | "Wang X.H."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/author | "Gao H.L."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/author | "Wei X.X."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/pages | "135-142"xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/title | "Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway."xsd:string |
| http://purl.uniprot.org/citations/26062743 | http://purl.uniprot.org/core/volume | "407"xsd:string |
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