http://purl.uniprot.org/citations/26065001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26065001 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies. We found that the clinical picture in these patients is highly variable suggesting a direct link between the monoclonal gammopathy and the neuropathy. Conversely, one-third of patients had a CIDP-like phenotype on electrodiagnostic testing and this was correlated with a low titer of anti-MAG antibodies and the absence of widening of myelin lamellae. Our data suggest that polyneuropathy associated with anti-MAG antibodies is less homogeneous than previously said and that the pathophysiology of the condition is likely to be heterogeneous as well with the self-antigen being MAG in most of the patients but possibly being another component of myelin in the others."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.org/dc/terms/identifier | "doi:10.1155/2015/450391"xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Vallat J.M."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Magy L."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Mathis S."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Ghorab K."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Caudie C."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Kabore R."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/author | "Lebeau P."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/name | "J Immunol Res"xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/pages | "450391"xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/title | "Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies."xsd:string |
http://purl.uniprot.org/citations/26065001 | http://purl.uniprot.org/core/volume | "2015"xsd:string |
http://purl.uniprot.org/citations/26065001 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26065001 |
http://purl.uniprot.org/citations/26065001 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26065001 |
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