| http://purl.uniprot.org/citations/26065921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26065921 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which cells acquire CSC properties such as drug resistance and tumour seeding ability are not fully understood. Here, we identified microRNA-27b (miR-27b) as a key regulator for the generation of a side-population in breast cancer cells that showed CSC properties, and also found that the anti-type II diabetes (T2D) drug metformin reduced this side-population via miR-27b-mediated repression of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), which is involved in T2D development. ENPP1 induced the generation of the side-population via upregulation of the ABCG2 transporter. ENPP1 was also identified as a substrate of the 26S proteasome, the activity of which is downregulated in CSCs. Overall, these results demonstrate that a T2D-associated gene plays an important role in tumour development and that its expression is strictly controlled at the mRNA and protein levels."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms8318"xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Tamura K."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Yamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Miyazaki H."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Takeshita F."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Ochiya T."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Kodaira M."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Minoura K."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/author | "Takahashi R.U."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/pages | "7318"xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/title | "Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1."xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26065921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26065921 |
| http://purl.uniprot.org/citations/26065921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26065921 |
| http://purl.uniprot.org/uniprot/#_B2RBY8-mappedCitation-26065921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26065921 |
| http://purl.uniprot.org/uniprot/#_P22413-mappedCitation-26065921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26065921 |
| http://purl.uniprot.org/uniprot/#_Q7Z3P5-mappedCitation-26065921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26065921 |
| http://purl.uniprot.org/uniprot/#_Q9NS95-mappedCitation-26065921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26065921 |
| http://purl.uniprot.org/uniprot/Q7Z3P5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26065921 |