| http://purl.uniprot.org/citations/26067405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26067405 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear receptor steroidogenic factor-1 (SF-1) plays essential roles in the development and function of the endocrine and reproductive systems. During embryogenesis, SF-1 is expressed in the ventromedial hypothalamic nucleus (VMH) and regulates the migration and terminal differentiation of the VMH neurons. Additionally, in situ hybridization data indicated SF-1 expression in the dorsal telencephalon at embryonic day (E) 13.5. In this study, we investigated the neocortical development in SF-1 knockout (KO) mouse embryos. The number of neurons was increased in the intermediate/subventricular zones and decreased in the cortical plate in the SF-1 KO embryos. SF-1 KO embryos produced more neural stem/progenitor cells, especially apical progenitor cells, and showed abnormal radial glial fiber morphology. The increase in neural stem/progenitor cells was caused by an increased S-phase fraction in the proliferative cells and the inhibition of cell cycle exit in these cells. The mRNA expression of the estrogen receptor ESRα was up-regulated and that of the estrogen synthetase Cyp19a1 was down-regulated in the dorsal telencephalon of SF-1 KO embryos. We showed that SF-1 is expressed in the dorsal telencephalon at E15.5 and E18.5, but not in adult animals. Our data demonstrated that SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development."xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2015.06.005"xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/author | "Komada M."xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/pages | "85-90"xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/title | "Involvement of SF-1 in neurogenesis and neuronal migration in the developing neocortex."xsd:string |
| http://purl.uniprot.org/citations/26067405 | http://purl.uniprot.org/core/volume | "600"xsd:string |
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