| http://purl.uniprot.org/citations/26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26068923 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim of the studyAssociation of two HLA class I variants with HIV-1 pretreatment viremia, CD4+ T cell count at the care-entry and CD4+ T cell nadir.Methods414 HIV-positive Caucasians (30% women) aged 19-73 years were genotyped for HLA-C -35 (rs9264942) and HLA-B*5701 variants. HIV-1 viral load, as well as CD4+ T cell count at care-entry and nadir, were compared across alleles, genotypes and haplotypes.ResultsHLA-C -35 C/C genotype was found in 17.6% patients, C/T genotype in 48.1%, and T/T genotype in 34.3% patients. HLA-B*5701 variant was present in 5.8% of studied population. HIV plasma viremia in the group with C allele was significantly lower (p=0.0002) compared to T/T group [mean:4.66 log (SD:1.03) vs. 5.07 (SD:0.85) log HIV-RNA copies/ml, respectively], while CD4+ T cell count at baseline was notably higher among C allele carriers compared to T/T homozygotes [median: 318 (IQR:127-537) cells/μl vs. median: 203 (IQR:55-410) cells/μl, respectively] (p=0.0007). Moreover, CD4+ T cell nadir among patients with C allele [median: 205 (IQR:83.5-390) cells/μl] was significantly higher compared to T/T group [median: 133 (IQR:46-328) cells/μl] (p=0.006). Among cases with HLA-B*5701 allele, significantly lower pretreatment viremia and higher baseline CD4+ T cell count were found (mean: 4.08 [SD: 1.2] vs. mean: 4.84 [SD:0.97] log HIV-RNA copies/ml, p=0.003 and 431 vs. 270 cells/μl, p=0.04, respectively) compared to HLA-B*5701 negative individuals. The lowest viremia (mean: 3.85 log [SD:1.3]) HIV-RNA copies/ml and the highest baseline and nadir CD4+ T cell [median: 476 (IQR:304-682) vs. median: 361 (IQR: 205-574) cells/μl, respectively) were found in individuals with HLA-B*5701(+)/HLA-C -35 C/C haplotype.ConclusionsHLA-C -35 C and HLA-B*5701 allele exert a favorable effect on the immunological (higher baseline and nadir CD4+ T cell count) and virologic (lower pretreatment HIV viral load) variables. This protective effect is additive for the compound HLA-B*5701(+)/HLA-C -35 C/C haplotype."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0127867"xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/author | "Urbanska A."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/author | "Parczewski M."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/author | "Leszczyszyn-Pynka M."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/author | "Aksak-Was B."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/pages | "e0127867"xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/title | "Protective Effect of HLA-B*5701 and HLA-C -35 Genetic Variants in HIV-Positive Caucasians from Northern Poland."xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26068923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26068923 |
| http://purl.uniprot.org/citations/26068923 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |
| http://purl.uniprot.org/uniprot/#_A0A068B2Z1-mappedCitation-26068923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26068923 |