| http://purl.uniprot.org/citations/26070483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26070483 | http://www.w3.org/2000/01/rdf-schema#comment | "Effector-T-cell-mediated immunity depends on the efficient localization of antigen-primed lymphocytes to antigen-rich non-lymphoid tissue, which is facilitated by the expression of a unique set of "homing" receptors acquired by memory T cells. We report that engagement of the hepatocyte growth factor (HGF) receptor c-Met by heart-produced HGF during priming in the lymph nodes instructs T cell cardiotropism, which was associated with a specialized homing "signature" (c-Met(+)CCR4(+)CXCR3(+)). c-Met signals facilitated T cell recruitment to the heart via the chemokine receptor CCR5 by inducing autocrine CCR5 ligand release. c-Met triggering was sufficient to support cardiotropic T cell recirculation, while CCR4 and CXCR3 sustained recruitment during heart inflammation. Transient pharmacological blockade of c-Met during T cell priming led to enhanced survival of heart, but not skin, allografts associated with impaired localization of alloreactive T cells to heart grafts. These findings suggest c-Met as a target for development of organ-selective immunosuppressive therapies."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2015.05.014"xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Haas R."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Cooper D."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Lombardi G."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Anderson G."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Mauro C."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Pitzalis C."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Marelli-Berg F.M."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Breckenridge R."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Coe D."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Steinbruchel D.A."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Kishore M."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Nadkarni S."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Bucy P."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/author | "Komarowska I."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/pages | "1087-1099"xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/title | "Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release."xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/26070483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26070483 |