| http://purl.uniprot.org/citations/26073967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26073967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26073967 | http://www.w3.org/2000/01/rdf-schema#comment | "Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches. All G-proteins require activation via exchange of GDP for GTP to carry out their respective tasks. Often, guanine-nucleotide exchange factors are essential to this process. During translation, EF-Tu:GTP transports aminoacylated tRNA to the ribosome. GTP is hydrolyzed during this process, and subsequent reactivation of EF-Tu is catalyzed by EF-Ts. The reaction path of guanine-nucleotide exchange is structurally poorly defined for EF-Tu and EF-Ts. We have determined the crystal structures of the following reaction intermediates: two structures of EF-Tu:GDP:EF-Ts (2.2 and 1.8Å resolution), EF-Tu:PO4:EF-Ts (1.9Å resolution), EF-Tu:GDPNP:EF-Ts (2.2Å resolution) and EF-Tu:GDPNP:pulvomycin:Mg(2+):EF-Ts (3.5Å resolution). These structures provide snapshots throughout the entire exchange reaction and suggest a mechanism for the release of EF-Tu in its GTP conformation. An inferred sequence of events during the exchange reaction is presented."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2015.06.011"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2015.06.011"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Knudsen C.R."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Knudsen C.R."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Nielsen T.K."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Nielsen T.K."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Van L.B."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Van L.B."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Thirup S.S."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/author | "Thirup S.S."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/name | "J. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/name | "J Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/pages | "10-21"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/pages | "10-21"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/title | "Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/title | "Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu."xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/26073967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26073967 |
| http://purl.uniprot.org/citations/26073967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26073967 |