| http://purl.uniprot.org/citations/26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26098214 | http://www.w3.org/2000/01/rdf-schema#comment | "The precise mechanisms that lead to parturition are incompletely defined. Surfactant protein-A (SP-A), which is secreted by fetal lungs into amniotic fluid (AF) near term, likely provides a signal for parturition; however, SP-A-deficient mice have only a relatively modest delay (~12 hours) in parturition, suggesting additional factors. Here, we evaluated the contribution of steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2), which upregulate SP-A transcription, to the parturition process. As mice lacking both SRC-1 and SRC-2 die at birth due to respiratory distress, we crossed double-heterozygous males and females. Parturition was severely delayed (~38 hours) in heterozygous dams harboring SRC-1/-2-deficient embryos. These mothers exhibited decreased myometrial NF-κB activation, PGF2α, and expression of contraction-associated genes; impaired luteolysis; and elevated circulating progesterone. These manifestations also occurred in WT females bearing SRC-1/-2 double-deficient embryos, indicating that a fetal-specific defect delayed labor. SP-A, as well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of surfactant dipalmitoylphosphatidylcholine, and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced in SRC-1/-2-deficient fetal lungs near term. Injection of PAF or SP-A into AF at 17.5 days post coitum enhanced uterine NF-κB activation and contractile gene expression, promoted luteolysis, and rescued delayed parturition in SRC-1/-2-deficient embryo-bearing dams. These findings reveal that fetal lungs produce signals to initiate labor when mature and that SRC-1/-2-dependent production of SP-A and PAF is crucial for this process."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci78544"xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Gao L."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Johnston J.M."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Mitsche M.A."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Mendelson C.R."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Condon J.C."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Renthal N.E."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/author | "Rabbitt E.H."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/pages | "2808-2824"xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/title | "Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition."xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/26098214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26098214 |
| http://purl.uniprot.org/citations/26098214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26098214 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26098214 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT2-mappedCitation-26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26098214 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY6-mappedCitation-26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26098214 |
| http://purl.uniprot.org/uniprot/#_D3YVJ7-mappedCitation-26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26098214 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-26098214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26098214 |