| http://purl.uniprot.org/citations/26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26099023 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositide-dependent kinase-1 (PDK1) is a key signaling molecule downstream of the phosphatidylinositol 3-kinase pathway and is a master regulator of multiple kinases in cells of epithelial and hematopoietic lineages. The physiological role of PDK1 in regulating skin and immune homeostasis is not known. Here we developed a mouse model in which PDK1 is conditionally ablated in activated CD4 T cells, regulatory T cells, and mature keratinocytes through OX40-Cre recombinase expression. The resultant mice (PDK1-CKO) spontaneously developed severe dermatitis, skin fibrosis, and systemic T helper type 2 immunity, succumbing by 11 weeks of age. Through a series of T-cell transfers, bone marrow reconstitutions, and crossing to lymphocyte-deficient backgrounds, we demonstrate that ablation of PDK1 in keratinocytes is the major driver of disease pathogenesis. PDK1-deficient keratinocytes exhibit intrinsic defects in the expression of key structural proteins including cytokeratin-10 and loricrin, resulting in increased keratinocyte turnover, which in turn triggers inflammation, T-cell recruitment, and immune-mediated destruction. Our results reveal PDK1 as a central regulator of keratinocyte homeostasis that prevents skin immune infiltration and inflammation."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2015.232"xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/author | "Owens D.M."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/author | "Farber D.L."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/pages | "2688-2696"xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/title | "Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease."xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/26099023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26099023 |
| http://purl.uniprot.org/citations/26099023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z3V6-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_B1ASL3-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_B7ZMX3-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z3X6-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z3X9-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z3Z9-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z400-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_F2Z4A5-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_Q3UHZ0-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_Q3UGN6-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |
| http://purl.uniprot.org/uniprot/#_Q8CD87-mappedCitation-26099023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26099023 |