| http://purl.uniprot.org/citations/26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26108442 | http://www.w3.org/2000/01/rdf-schema#comment | "Leaf primordia are born around meristem-containing stem cells at shoot apices, grow along three axes (proximal-distal, adaxial-abaxial, medial-lateral), and develop into flat symmetric leaves with adaxial-abaxial polarity. Axis development and polarity specification of Arabidopsis leaves require a network of genes for transcription factor-like proteins and small RNAs. Here, we summarize present understandings of adaxial-specific genes, ASYMMETRIC LEAVES1 (AS1) and AS2. Their complex (AS1-AS2) functions in the regulation of the proximal-distal leaf length by directly repressing class 1 KNOX homeobox genes (BP, KNAT2) that are expressed in the meristem periphery below leaf primordia. Adaxial-abaxial polarity specification involves antagonistic interaction of adaxial and abaxial genes including AS1 and AS2 for the development of two respective domains. AS1-AS2 directly represses the abaxial gene ETTIN/AUXIN RESPONSE FACTOR3 (ETT/ARF3) and indirectly represses ETT/ARF3 and ARF4 through tasiR-ARF. Modifier mutations have been identified that abolish adaxialization and enhance the defect in the proximal-distal patterning in as1 and as2. AS1-AS2 and its modifiers synergistically repress both ARFs and class 1 KNOXs. Repression of ARFs is critical for establishing adaxial-abaxial polarity. On the other hand, abaxial factors KANADI1 (KAN1) and KAN2 directly repress AS2 expression. These data delineate a molecular framework for antagonistic gene interactions among adaxial factors, AS1, AS2, and their modifiers, and the abaxial factors ARFs as key regulators in the establishment of adaxial-abaxial polarity. Possible AS1-AS2 epigenetic repression and activities downstream of ARFs are discussed."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.org/dc/terms/identifier | "doi:10.1002/wdev.196"xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/author | "Kojima S."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/author | "Nakagawa A."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/author | "Machida Y."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/author | "Machida C."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/name | "Wiley Interdiscip Rev Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/pages | "655-671"xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/title | "The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26108442 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26108442 |
| http://purl.uniprot.org/citations/26108442 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26108442 |
| http://purl.uniprot.org/uniprot/#_A0A1P8ANX6-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_A0A1P8ATH7-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_A0A1P8ATI2-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_A0A1P8AZW3-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_A0A1P8BF20-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_O04479-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_P46640-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_O23661-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_O80931-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |
| http://purl.uniprot.org/uniprot/#_Q9C616-mappedCitation-26108442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26108442 |