| http://purl.uniprot.org/citations/26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26109047 | http://www.w3.org/2000/01/rdf-schema#comment | "TORC1 (target of rapamycin complex 1) plays a central role in regulating growth, development, and behavior in response to nutrient cues. We previously showed that leucine-derived monomethyl branched-chain fatty acids (mmBCFAs) and derived glucosylceramide promote intestinal TORC1 activity for post-embryonic development and foraging behavior in Caenorhabditis elegans. Here we show that clathrin/adaptor protein 1 (AP-1)-dependent intestinal apical membrane polarity and polarity-dependent localization of the vacuolar-type H(+)-ATPase (V-ATPase) mediate the impact of the lipid pathway on intestinal TORC1 activation. Moreover, NPRL-3 represses mmBCFA-dependent intestinal TORC1 activity at least partly by regulating apical membrane polarity. Our results provide new insights into TORC1 regulation by lipids and membrane polarity in a specific tissue."xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.263483.115"xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/pages | "1218-1223"xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/title | "Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/26109047 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A061ACM2-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A061ACP8-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A061ADW6-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A061AJ42-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A061AKT4-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ARH7-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
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| http://purl.uniprot.org/uniprot/#_C0HLB3-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_C0HLB4-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A4V0IIR6-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A4V0IJW4-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |
| http://purl.uniprot.org/uniprot/#_A0A2C9C2Y0-mappedCitation-26109047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109047 |