| http://purl.uniprot.org/citations/26109379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26109379 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity. Chemokines are credited with guiding the multistep recruitment of CD8(+) T cells across tumour vessels. However, the multiplicity of chemokines within tumours has obscured the contributions of individual chemokine receptor/chemokine pairs to this process. Moreover, recent studies have challenged whether T cells require chemokine receptor signalling at effector sites. Here we investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma. These studies reveal a non-redundant role for Gαi-coupled CXCR3 in stabilizing intravascular adhesion and extravasation of adoptively transferred CD8(+) effectors that is indispensable for therapeutic efficacy. In contrast, functional CCR2 and CCR5 on CD8(+) effectors fail to support trafficking despite the presence of intratumoral cognate chemokines. Taken together, these studies identify CXCR3-mediated trafficking at the tumour vascular interface as a critical checkpoint to effective T-cell-based cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms8458"xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Matsuzaki J."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Luster A.D."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Frelinger J.G."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Evans S.S."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Gajewski T.F."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Odunsi K."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Fisher D.T."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Muhitch J.B."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Gaulin N.B."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Ku A.W."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Mikucki M.E."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/author | "Skitzki J.J."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/pages | "7458"xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/title | "Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints."xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26109379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26109379 |
| http://purl.uniprot.org/citations/26109379 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26109379 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-26109379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109379 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-26109379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109379 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS26-mappedCitation-26109379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26109379 |