| http://purl.uniprot.org/citations/26114424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26114424 | http://www.w3.org/2000/01/rdf-schema#comment | "RhoH, an atypical small Rho-family GTPase, critically regulates thymocyte differentiation through the coordinated interaction with Lck and Zap70. Therefore, RhoH deficiency causes defective T cell development, leading to a paucity of mature T cells. Since there has been no gain-of-function study on RhoH before, we decided to take a transgenic approach to assess how the overexpression of RhoH affects the development of T cells. Although RhoH transgenic (RhoHtg) mice expressed three times more RhoH protein than wild-type mice, β-selection, positive, and negative selection in the thymus from RhoHtg mice were unaltered. However, transgenic introduction of RhoH into Rag2 deficient mice resulted in the generation of CD4+ CD8+ (DP) thymocytes, indicating that overexpression of RhoH could bypass β-selection without TCRβ gene rearrangement. This was confirmed by the in vitro development of DP cells from Rag2-/-RhoHtg DN3 cells on TSt-4/Dll-1 stroma in an Lck dependent manner. Collectively, our results indicate that an excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0131047"xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/author | "Shirai M."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/author | "Oda H."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/author | "Tamehiro N."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/pages | "e0131047"xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/title | "Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint."xsd:string |
| http://purl.uniprot.org/citations/26114424 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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